Product Overview
Compound: SS‑31 (Elamipretide, Bendavia, MTP‑131), a mitochondria-targeted tetrapeptide (D‑Arg‑Dmt‑Lys‑Phe‑NH₂)
Form: Lyophilized powder, research-grade purity ≥95‑99%.
For laboratory research only—NOT for human or veterinary use.
Batch-tested ≥95‑99% purity by HPLC. COA available upon request — email providers@theratideusa.com.
- Antioxidant & mitochondrial protector: Scavenges ROS, stabilizes mitochondrial membranes, prevents permeability pore formation, and supports ATP production :contentReference[oaicite:1]{index=1}.
- Cardio & renal disease: Shows benefits in kidney and heart disease models by reducing oxidative damage and fibrosis :contentReference[oaicite:2]{index=2}.
- Neurological health: Protects hippocampal cells from oxidative stress, preserves cognition and cerebrovascular function in aged mice :contentReference[oaicite:3]{index=3}.
- Skeletal muscle & aging: Rapidly reverses age-related mitochondrial deficits and improves muscle energetics and endurance :contentReference[oaicite:4]{index=4}.
- Clinical trials: Under evaluation for Barth syndrome, mitochondrial myopathies, and heart failure; mixed outcomes :contentReference[oaicite:5]{index=5}.
Evidence includes preclinical and clinical data, no regulatory approvals yet.
What is SS‑31 used for?
Investigated as a mitochondrial protector in kidney, heart, brain, and muscle disease models.
How does it work?
Targets mitochondrial cardiolipin to improve electron transport, reduce ROS, stabilize membrane structure and function :contentReference[oaicite:6]{index=6}.
Any clinical use?
Tested in Phase II/III trials (e.g., Barth syndrome, heart failure), with mixed results :contentReference[oaicite:7]{index=7}.
Typical dosing?
Preclinical: 3–40 mg/kg (IP/SubQ). Clinical dosages vary by trial protocol :contentReference[oaicite:8]{index=8}.
Known side effects?
Generally well tolerated; injection site redness possible in SubQ studies :contentReference[oaicite:9]{index=9}.
For research use only—not for human or veterinary use, nor intended as a dietary supplement.
Safety: Handle with appropriate lab protocols, PPE, and store at ≤\u201320 °C.
FDA Notice: Statements not evaluated by FDA. Not intended to diagnose, treat, cure, or prevent disease.
