PN5 -5mg
$159.99
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Lyophilized Peptides:
These peptides are freeze-dried, a process that helps support shelf life while preserving the purity and integrity of the peptides during storage.
These peptides are freeze-dried, a process that helps support shelf life while preserving the purity and integrity of the peptides during storage.
COA Documentation:
Every product is supported by batch-specific documentation so researchers can review purity, identity, and quality information before use.
Every product is supported by batch-specific documentation so researchers can review purity, identity, and quality information before use.
99%+ Research-Grade Purity:
Our research peptide products are offered in a 99%+ research-grade purity format and are tested to confirm quality, identity, and consistency.
Our research peptide products are offered in a 99%+ research-grade purity format and are tested to confirm quality, identity, and consistency.
Product Overview
Product Information
Compound: PN5 (Pinus densiflora-derived antimicrobial peptide)
Format: Lyophilized Powder, ≥95% purity
Contents: 10 mg vial
For research use only—NOT for human or veterinary consumption.
COA (Certificate of Analysis)
Each batch is tested by a third-party lab for sequence verification and purity. COAs available upon request—email providers@theratideusa.com.
Research
PN5 is an α-helical antimicrobial peptide, originally isolated from Korean red pine needles (Pinus densiflora), with strong activity across Gram-positive and -negative bacteria :contentReference[oaicite:1]{index=1}.
- Broad-spectrum antimicrobial: Effective against MDR E. coli, S. aureus, and foodborne pathogens (MICs 8–128 μg/mL), with minimal cytotoxicity or resistance development :contentReference[oaicite:2]{index=2}.
- Mechanism of action: Disrupts bacterial membranes via pore formation (“toroidal” mechanism) and maintains stability in protease-rich environments :contentReference[oaicite:3]{index=3}.
- Anti-inflammatory effects: Suppresses LPS-induced cytokine release by inhibiting NF‑κB and MAPK signaling in macrophages; demonstrated reduction of inflammation in LPS‑induced septic mouse liver models :contentReference[oaicite:4]{index=4}.
Shows promising preclinical potential as an antimicrobial and immunomodulatory agent.
FAQ
What is PN5?
A novel antimicrobial peptide derived from pine needles with demonstrated efficacy against drug-resistant pathogens.
Does PN5 cause resistance?
No bacterial resistance was observed during extended exposure trials in the referenced study :contentReference[oaicite:5]{index=5}.
What are its main applications?
Useful for research in antimicrobial development, sepsis models, and membrane-active peptide studies.
Legal Disclaimer
This product is sold for research use only and is not intended for therapeutic, diagnostic, or human use. Refer to our Terms & Conditions before purchasing.
Safety Information: Handle using laboratory-grade protocols. Keep securely stored away from unauthorized access.
FDA Notice: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
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