FOXO4-DRI 10mg
$318.99
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Availability:
In Stock
Lyophilized Peptides:
These peptides are freeze-dried, a process that helps support shelf life while preserving the purity and integrity of the peptides during storage.
These peptides are freeze-dried, a process that helps support shelf life while preserving the purity and integrity of the peptides during storage.
COA Documentation:
Every product is supported by batch-specific documentation so researchers can review purity, identity, and quality information before use.
Every product is supported by batch-specific documentation so researchers can review purity, identity, and quality information before use.
99%+ Research-Grade Purity:
Our research peptide products are offered in a 99%+ research-grade purity format and are tested to confirm quality, identity, and consistency.
Our research peptide products are offered in a 99%+ research-grade purity format and are tested to confirm quality, identity, and consistency.
Product Overview
Product Information
Compound: FOXO4‑DRI (D‑Retro‑Inverso peptide, “Proxofim”)
Form: 10 mg vial, ≥99 % purity; cell-penetrating senolytic targeting FOXO4–p53 interaction :contentReference[oaicite:1]{index=1}
For research use only—NOT for human or veterinary use.
COA (Certificate of Analysis)
Batch tested ≥99 % purity by HPLC. COA available upon request—contact providers@theratideusa.com.
Research
- Senolytic action: Disrupts FOXO4–p53 binding to trigger selective apoptosis in senescent cells :contentReference[oaicite:2]{index=2}.
- Cartilage health & osteoarthritis: Removes senescent chondrocytes (PDL9) and reduces cartilage-degrading markers MMP12/MMP13 :contentReference[oaicite:3]{index=3}.
- Kidney & testicular rejuvenation: Improves renal function and restores testosterone levels & Leydig cell health in aged mice via senescent cell clearance :contentReference[oaicite:4]{index=4}.
- Anti-fibrosis & oncology uses: Shows reduced lung fibrosis in bleomycin models and lethal effect on senescent tumor cells while sparing healthy ones :contentReference[oaicite:5]{index=5}.
All findings are from preclinical in vitro or animal models; no human clinical data available yet.
FAQ
What is FOXO4‑DRI used for?
Research focuses on senolytic therapy, tissue rejuvenation, osteoarthritis, fibrosis reversal, renal and testicular regeneration.
How does it work?
Acts as a D‑retro‑inverso peptide to displace p53 from FOXO4 in senescent cells, triggering apoptosis while sparing healthy cells :contentReference[oaicite:6]{index=6}.
Any human trials?
Currently limited to lab/animal studies—no published human data yet :contentReference[oaicite:7]{index=7}.
Suggested handling?
Reconstitute freshly; store lyophilized at ≤ –20 °C; protect from light and moisture.
Legal Disclaimer
For laboratory research use only—not for human or veterinary use, nor as a dietary supplement.
Safety: Use appropriate lab protocols, protective gear, and secure storage.
FDA Notice: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
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