Product Overview
Compound: PN5 (Pinus densiflora-derived antimicrobial peptide)
Format: Lyophilized Powder, ≥95% purity
Contents: 10 mg vial
For research use only—NOT for human or veterinary consumption.
Each batch is tested by a third-party lab for sequence verification and purity. COAs available upon request—email providers@theratideusa.com.
PN5 is an α-helical antimicrobial peptide, originally isolated from Korean red pine needles (Pinus densiflora), with strong activity across Gram-positive and -negative bacteria :contentReference[oaicite:1]{index=1}.
- Broad-spectrum antimicrobial: Effective against MDR E. coli, S. aureus, and foodborne pathogens (MICs 8–128 μg/mL), with minimal cytotoxicity or resistance development :contentReference[oaicite:2]{index=2}.
- Mechanism of action: Disrupts bacterial membranes via pore formation (“toroidal” mechanism) and maintains stability in protease-rich environments :contentReference[oaicite:3]{index=3}.
- Anti-inflammatory effects: Suppresses LPS-induced cytokine release by inhibiting NF‑κB and MAPK signaling in macrophages; demonstrated reduction of inflammation in LPS‑induced septic mouse liver models :contentReference[oaicite:4]{index=4}.
Shows promising preclinical potential as an antimicrobial and immunomodulatory agent.
What is PN5?
A novel antimicrobial peptide derived from pine needles with demonstrated efficacy against drug-resistant pathogens.
Does PN5 cause resistance?
No bacterial resistance was observed during extended exposure trials in the referenced study :contentReference[oaicite:5]{index=5}.
What are its main applications?
Useful for research in antimicrobial development, sepsis models, and membrane-active peptide studies.
This product is sold for research use only and is not intended for therapeutic, diagnostic, or human use. Refer to our Terms & Conditions before purchasing.
Safety Information: Handle using laboratory-grade protocols. Keep securely stored away from unauthorized access.
FDA Notice: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
