MOTS-C

TheraTide USA

$54.99 - $99.99
MOTS-C
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Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

98.5% vs. 99% Purity: Both grades go through our lyophilization process in our US-based facility and are tested for quality at a third party lab. While the 99%+ purity grade is our highest reference grade product line, the 98.5% purity variants still exceed US pharmaceutical standards.

Product Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded by the mitochondrial genome. Discovered in 2015, MOTS-c has been found to play important roles in regulating metabolism, insulin sensitivity, and energy homeostasis. Research has shown that MOTS-c can improve glucose metabolism in skeletal muscle, reduce obesity, and potentially delay age-related physical decline.

  • Molecular Formula: C101H152N28O22S2
  • Molecular Weight: 2174.6 g/mol
  • Purity: ≥ 98.5%
  • Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
  • Available Sizes: 5mg, 10mg
  • Form: Lyophilized or Non-Lyophilized Powder

Our MOTS-c products undergo rigorous third-party testing to ensure the highest purity and quality standards. Certificates of Analysis (COA) are available upon request and include detailed information on:

  • Purity Levels
  • Peptide Sequence Verification
  • Contaminant Screening
  • Batch Numbers
  • Testing Dates

To request a COA for your specific batch, please contact our customer support team with your order details.

MOTS-c has been extensively studied for its metabolic and anti-aging properties. Key research findings include:

  • Metabolic Regulation: MOTS-c enhances insulin sensitivity and glucose metabolism, making it a potential therapeutic agent for metabolic disorders such as type 2 diabetes and obesity.
  • Energy Homeostasis: It activates the AMPK pathway, a key regulator of cellular energy balance, leading to increased lipid oxidation and improved metabolic flexibility.
  • Anti-Inflammatory Effects: MOTS-c has been shown to reduce inflammation by modulating cytokine production and inhibiting pro-inflammatory signaling pathways.
  • Exercise Mimetic: Research suggests that MOTS-c can mimic the effects of exercise by enhancing muscle function and endurance.

References:

  1. Lee, C., Zeng, J., Drew, B. G., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. https://doi.org/10.1016/j.cmet.2015.02.009
  2. Kim, K. H., Son, J. M., Benayoun, B. A., & Lee, C. (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 28(4), 516–524.e7. https://doi.org/10.1016/j.cmet.2018.06.008
  3. Lu, H., & Zhang, Y. (2022). Mitochondria-derived peptide MOTS-c: A novel regulator of metabolism. Frontiers in Endocrinology, 13, 888401. https://doi.org/10.3389/fendo.2022.888401

What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide that plays a significant role in regulating metabolism, insulin sensitivity, and energy homeostasis. It is being studied for its potential therapeutic applications in various conditions, including diabetes, cardiovascular diseases, and age-related disorders.

How does MOTS-c work?

MOTS-c activates the AMPK pathway, leading to improved glucose uptake, enhanced lipid oxidation, and increased energy expenditure. It also modulates inflammatory responses and supports mitochondrial function.

Is MOTS-c safe?

As of now, the safety profile of MOTS-c is not fully established due to limited research. Early studies suggest it may be well-tolerated, but potential risks and side effects are not yet fully understood. It is crucial to use MOTS-c under the supervision of a qualified healthcare provider and to rely on reputable sources if available.

Do I need a prescription for MOTS-c?

Yes, in most regions, MOTS-c is classified as a research chemical and is not approved for general use. It typically requires a prescription for medical or research purposes. Regulations vary by country, so it's essential to check local laws and consult with a healthcare professional before obtaining or using MOTS-c.

Can MOTS-c help with fat loss?

Yes, one of the potential benefits of MOTS-c is promoting fat loss by enhancing the body's ability to break down stored fat and improve metabolic rate. However, its effectiveness for fat loss in humans is still being studied, and more research is needed to confirm these effects.

This product is sold as a pure compound for research purposes only and is not intended for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement but a pure substance, sold as a raw material. We attest exclusively to the quality, purity, and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material.

All products offered by TheraTide USA are strictly intended for research and development purposes only.

None of the statements on this website have been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

TheraTide USA is a research chemical supplier. We are not a compounding pharmacy or a chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act.