Product Overview
Compound: KPV (Lysine–Proline–Valine), a C-terminal tripeptide fragment of α‑MSH.
Form: Lyophilized powder, US-made research-grade, typically ≥98% purity.
Research use only—NOT for human or veterinary application.
Batch-tested purity ≥98%. COA available on request—email providers@theratideusa.com.
- Anti‑Inflammatory / Mucosal Healing: In UC mouse models and cell lines, KPV reduces NFκB signaling, accelerates mucosal repair, and lowers TNF‑α expression in colonic epithelial cells :contentReference[oaicite:1]{index=1}.
- PepT1‑mediated Uptake: KPV is transported into intestinal and immune cells via PepT1, enabling its anti‑inflammatory actions :contentReference[oaicite:2]{index=2}.
- Inflammatory Bowel Disease (IBD) Models: Oral KPV (in drinking water) reduced colitis incidence and pro-inflammatory cytokines in DSS and TNBS mouse models :contentReference[oaicite:3]{index=3}.
- Wound Healing & Antimicrobial: Promotes tissue repair, reduces infection, accelerates wound closure, and may support skin health including psoriasis :contentReference[oaicite:4]{index=4}.
- Delivery Advances: HA‑coated nanoparticle formulations enhance targeted delivery to inflamed colon, improving efficacy in ulcerative colitis models :contentReference[oaicite:5]{index=5}.
All findings are from preclinical animal and in vitro studies; no human clinical trials.
What is KPV used for?
Research into gut inflammation (e.g., colitis), wound healing, anti-inflammatory, and antimicrobial effects.
How is it administered?
Subject to study—oral, IV, IP, topical, and nanoparticle delivery methods have been reported in preclinical studies.
Is it transportable to tissues?
Yes—pepptide is uptake via PepT1 transporter, accessing intestinal and immune cells :contentReference[oaicite:6]{index=6}.
Side effects?
Preclinical results report no significant toxicity or adverse events in animal studies.
For research use only—NOT for use in humans, animals, or as dietary supplements.
Safety: Use under laboratory-grade conditions, with appropriate PPE; store at ≤–20 °C.
FDA Notice: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent disease.
