IGF-1 LR3 1mg

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IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is a synthetic, modified construct of insulin-like growth factor-1. Because IGF-1 LR3 does not bind to IGF-1 binding proteins very well, it remains active up to 120 times longer than standard IGF-1. This results in improved half-life for the peptide and thus increased activity. IGF-1 LR3 enhances cell division and growth, boosts fat metabolism, and increases muscle repair and hypertrophy by inhibiting myostatin.

Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

98.5% vs. 99% Purity: Both grades go through our lyophilization process in our US-based facility and are tested for quality at a third party lab. While the 99%+ purity grade is our highest reference grade product line, the 98.5% purity variants still exceed US pharmaceutical standards.

Product Overview

Product Overview

IGF-1 LR3 Overview

IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analogue of IGF-1, a naturally occurring growth factor in the human body. IGF-1 is an important mediator of growth hormone (GH) effects, promoting muscle growth, repair, and regeneration. The “Long R3” modification significantly increases its half-life and bioavailability, making it more potent and longer-acting than natural IGF-1.

Peptide Structure

IGF-1 LR3 Structure

Research Applications

In research studies, IGF-1 LR3 has demonstrated potential in:

  • Promoting muscle hypertrophy and preventing atrophy in animal models
  • Enhancing wound healing and tissue repair
  • Improving recovery following nerve injuries
  • Investigating its role in neuroprotection and cognitive function

Due to its extended half-life, IGF-1 LR3 remains active in the body for longer periods, making it a preferred variant for research compared to native IGF-1.

Longevity Research

IGF-1 LR3 is also under investigation for its potential role in longevity and age-related diseases. Research has explored its ability to mitigate sarcopenia (age-related muscle loss), improve bone density, and contribute to overall tissue maintenance and regeneration in aging populations.

Longevity Infographic

Referenced Citations

  1. “Adipose Tissue-Derived Stem Cell Secreted IGF-1 Protects Myoblasts from the Negative Effect of Myostatin.” [Online]. Available: https://www.hindawi.com/journals/bmri/2014/129048/
  2. N. Li, et al., “Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis,” Endocrinology, vol. 157, no. 1, pp. 282–291, Jan. 2016.
  3. E. Corpas, et al., “Human growth hormone and human aging,” Endocr. Rev., vol. 14, no. 1, pp. 20–39, Feb. 1993.
  4. W. E. Sonntag, et al., “Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging,” J. Gerontol. A Biol. Sci. Med. Sci., vol. 67, no. 6, pp. 587–598, Jun. 2012.
  5. “IGF-I/IGFBP system: metabolism outline and physical exercise.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/22714057
  6. B. Y. Hanaoka, et al., “Implications of glucocorticoid therapy in idiopathic inflammatory myopathies,” Nat. Rev. Rheumatol., vol. 8, no. 8, pp. 448–457, Aug. 2012.
  7. A Philippou, et al., J Musculoskelet Neuronal Interact, 2007 [Semantic Scholar]
  8. A Philippou, et al., In vivo, 2009 [Iiar Journals]

All Articles and Product Information Provided On This Website Are For Informational and Educational Purposes Only.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

All products offered by TheraTide USA are strictly intended for research and development purposes only.

None of the statements on this website have been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

TheraTide USA is a research chemical supplier. We are not a compounding pharmacy or a chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act.