Epithalon 10mg

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Epithalon 10mg
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Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed in Russia in the 1980s for its potential anti-aging and regenerative properties. It works by activating the enzyme telomerase, which protects and lengthens telomeres — the protective caps on DNA — helping to maintain cellular health and delay age-related deterioration. Research has shown it may extend lifespan, improve immune and reproductive function, and support skin, eye, and circadian rhythm health. Epithalon has also demonstrated potential in reducing tumor growth and enhancing DNA repair, making it a focus of longevity and cancer research. All information provide here is for research purposes only.

Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

98.5% vs. 99% Purity: Both grades go through our lyophilization process in our US-based facility and are tested for quality at a third party lab. While the 99%+ purity grade is our highest reference grade product line, the 98.5% purity variants still exceed US pharmaceutical standards.

Product Overview

Product Overview

What Is Epithalon?

Epithalon (also known as Epitalon, Epithalone or Epithalamin) is a short synthetic peptide known to activate the telomerase enzyme and stimulate melatonin release. First developed in Russia in the 1980s, epithalon has been shown to delay age-related changes in reproductive and immune systems and increase the life span of mice and rats. Though it is primarily of interest in anti-aging research, epithalon has shown significant effects in certain types of cancer, infectious disease, and in DNA regulation.

Epithalon Structure

Epithalon Structure

Sequence: Ala-Glu-Asp-Gly
Molecular Formula: C14H22N4O9
Molecular Weight: 390.349 g/mol
PubChem CID: 219042
CAS Number: 307297-39-8

Epithalon Research

1. The Role of Telomerase in the Anti-Aging Effects of Epithalon

Research in insects and rodents has shown that epithalon prolongs life by eliminating free radicals and activating telomerase, which protects telomeres and prevents DNA damage. In mice prone to heart disease and cancer, epithalon increased lifespan by up to 27%.

2. Epithalon and DNA Activation

Epithalon interacts directly with DNA to turn on and enhance the expression of genes like CD5, IL-2, MMP2, and Tram1. This enhances immune system function and tissue maintenance while reducing age-related decline. Epithalon also boosts interferon gamma in aging lymphocytes, improving immune defense.

  • CD5 – Leads to immune cell differentiation
  • IL-2 – Regulates white blood cell production
  • MMP2 – Maintains extracellular matrix and reduces inflammation
  • Tram1 – Enhances protein production
  • AANAT – Boosts melatonin production
  • pCREB – Regulates circadian rhythm and anti-tumor effects
  • Telomerase – Increases cell longevity

3. Epithalon and Skin Health

Epithalon activates fibroblasts and enhances MMP2 gene activity, improving skin repair and reducing the effects of aging on skin structure.

4. Epithalon and Tumor Growth

Research shows epithalon reduces tumor growth and metastasis in rats, and may play a role in regulating genes (like PER1) involved in cancer progression.

5. Epithalon and Melatonin Secretion

Epithalon restores melatonin secretion and circadian rhythm in aged animals by regulating AANAT and pCREB genes.

6. Epithalon and Eyesight

In rat studies of retinitis pigmentosa, epithalon improved outcomes in 90% of cases, preserving retinal structure and function.

Referenced Citations

  1. V. N. Anisimov et al., “Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats,” Mech. Ageing Dev., 1998.
  2. V. K. Khavinson et al., “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells,” Bull. Exp. Biol. Med., 2003.
  3. T. A. Dzhokhadze et al., “Functional regulation of genome with peptide bioregulators,” Georgian Med. News, 2013.
  4. V. N. Anisimov et al., “Effect of Epithalon on biomarkers of aging,” Biogerontology, 2003.
  5. V. K. Khavinson et al., “Short cell-penetrating peptides: gene promoter interactions,” Bull. Exp. Biol. Med., 2013.
  6. N. S. Lin’kova et al., “Peptide Ala-Glu-Asp-Gly and immune response,” Adv. Gerontol., 2012.
  7. N. I. Chalisova et al., “Short peptides stimulate skin regeneration,” Adv. Gerontol., 2014.
  8. More available upon request.

All Articles and Product Information Provided On This Website Are For Informational and Educational Purposes Only.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

All products offered by TheraTide USA are strictly intended for research and development purposes only.

None of the statements on this website have been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

TheraTide USA is a research chemical supplier. We are not a compounding pharmacy or a chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act.