Product Overview
Compound: Cagrilintide TRE, a long-acting acylated analog of amylin (AMYR/CTR agonist)
Form: ≥99% purity lyophilized, US-made peptide :contentReference[oaicite:1]{index=1}
For research use only—NOT for human or veterinary use.
Batch tested ≥99% purity by third-party lab. COAs available upon request—email providers@theratideusa.com.
- Weight loss in humans: Phase II showed once-weekly dosing led to average 6–10% weight loss vs ~3% with placebo; 4.5 mg dose outperformed liraglutide 3 mg :contentReference[oaicite:2]{index=2}.
- Mechanism: Activates amylin and calcitonin receptors to suppress appetite via satiety and hunger pathways :contentReference[oaicite:3]{index=3}.
- CagriSema combo: Combined with semaglutide, CagriSema in Phase III produced ~22–23% weight loss over 68 weeks, exceeding monotherapy arms :contentReference[oaicite:4]{index=4}.
- Diabetes & metabolic support: Improved glycemic control and weight loss demonstrated in type 2 diabetes (CagriSema trials) :contentReference[oaicite:5]{index=5}.
- Safety: Generally well-tolerated; GI side effects (nausea, constipation, diarrhea) and injection-site reactions most common :contentReference[oaicite:6]{index=6}.
All data from clinical trials (Phase II/III); preclinical metabolic and obesity studies support human findings.
What is it studied for?
Made for obesity and type 2 diabetes via appetite suppression and improved satiety :contentReference[oaicite:7]{index=7}.
How does it work?
Targets amylin and calcitonin receptors to slow gastric emptying and enhance fullness :contentReference[oaicite:8]{index=8}.
What dose is used?
Clinical trials have used 0.3–4.5 mg weekly; higher doses yield greater weight loss :contentReference[oaicite:9]{index=9}.
What about side effects?
Mostly mild GI (nausea, constipation, diarrhea) and injection-site reactions; symptoms abate over time :contentReference[oaicite:10]{index=10}.
Storage?
Store lyophilized at ≤–20 °C; reconstitute freshly before use; keep away from light.
For laboratory research only—not for human or veterinary use, nor as a dietary supplement.
Safety: Handle under professional lab protocols with proper gear.
FDA Notice: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
