Product Overview
Compound: 5‑Amino‑1‑methylquinolinium (5‑Amino‑1MQ), a potent inhibitor of Nicotinamide N‑Methyltransferase (NNMT)
Form: Capsules (e.g., 50 mg, 60 count); research-grade high purity.
For laboratory research use only—NOT for human or veterinary use.
Batch-certified purity ≥98% (HPLC). COA available upon request—email providers@theratideusa.com.
- NNMT inhibition & fat reduction: Blocks NNMT (IC₅₀ ≈1–2 µM), reducing methylation of nicotinamide, increasing cellular NAD⁺ and SAM levels :contentReference[oaicite:1]{index=1}.
- Weight loss in mice: In diet-induced obese mice, 5‑Amino‑1MQ plus low-fat diet normalized adiposity, reduced fat pad volume & cholesterol without affecting food intake :contentReference[oaicite:2]{index=2}.
- Muscle strength & recovery: Aged mice treated with 5‑Amino‑1MQ showed 25% strength improvement and better endurance than exercise alone :contentReference[oaicite:3]{index=3}.
- Metabolic improvement: Suppresses fat cell formation, improves metabolic markers (cholesterol, adiposity, gut microbiome) :contentReference[oaicite:4]{index=4}.
- Safety profile: Preclinical data shows metabolic benefit without appetite suppression or toxicity :contentReference[oaicite:5]{index=5}.
Data is from preclinical models; no human clinical trials to date.
What is its purpose?
Research tool for targeting NNMT to study metabolism, obesity, NAD⁺/SAM regulation, and muscle health.
How is it dosed?
In mice: ~20 mg/kg SC, t.i.d., for ~2 weeks; human dosing not established. :contentReference[oaicite:6]{index=6}
What effects to expect?
Reduced fat mass, normalized cholesterol, metabolic shift—no appetite change; enhanced strength/endurance in aged mice :contentReference[oaicite:7]{index=7}.
Are there side effects?
Preclinical results report no appetite suppression or serious adverse events at effective doses.
Administration?
Typically oral capsules or SC in lab settings; purification and handling under standard lab safety.
Human trials?
None published; current findings limited to animal and in vitro studies.
For research use only—not intended for human or veterinary use or as a dietary supplement.
Safety: Use under professional lab protocols; store at ≤–20 °C.
FDA Notice: Statements have not been evaluated by FDA. Not intended to diagnose, treat, cure, or prevent any disease.