5-Amino-1MQ Powder

TheraTide USA

$157.29 - $362.99
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Product Overview

 

Compound: 5‑Amino‑1‑methylquinolinium (5‑Amino‑1MQ), a potent inhibitor of Nicotinamide N‑Methyltransferase (NNMT)

Form: Capsules (e.g., 50 mg, 60 count); research-grade high purity.

For laboratory research use only—NOT for human or veterinary use.

Batch-certified purity ≥98% (HPLC). COA available upon request—email providers@theratideusa.com.

  • NNMT inhibition & fat reduction: Blocks NNMT (IC₅₀ ≈1–2 µM), reducing methylation of nicotinamide, increasing cellular NAD⁺ and SAM levels :contentReference[oaicite:1]{index=1}.
  • Weight loss in mice: In diet-induced obese mice, 5‑Amino‑1MQ plus low-fat diet normalized adiposity, reduced fat pad volume & cholesterol without affecting food intake :contentReference[oaicite:2]{index=2}.
  • Muscle strength & recovery: Aged mice treated with 5‑Amino‑1MQ showed 25% strength improvement and better endurance than exercise alone :contentReference[oaicite:3]{index=3}.
  • Metabolic improvement: Suppresses fat cell formation, improves metabolic markers (cholesterol, adiposity, gut microbiome) :contentReference[oaicite:4]{index=4}.
  • Safety profile: Preclinical data shows metabolic benefit without appetite suppression or toxicity :contentReference[oaicite:5]{index=5}.

Data is from preclinical models; no human clinical trials to date.

What is its purpose?
Research tool for targeting NNMT to study metabolism, obesity, NAD⁺/SAM regulation, and muscle health.

How is it dosed?
In mice: ~20 mg/kg SC, t.i.d., for ~2 weeks; human dosing not established. :contentReference[oaicite:6]{index=6}

What effects to expect?
Reduced fat mass, normalized cholesterol, metabolic shift—no appetite change; enhanced strength/endurance in aged mice :contentReference[oaicite:7]{index=7}.

Are there side effects?
Preclinical results report no appetite suppression or serious adverse events at effective doses.

Administration?
Typically oral capsules or SC in lab settings; purification and handling under standard lab safety.

Human trials?
None published; current findings limited to animal and in vitro studies.

For research use only—not intended for human or veterinary use or as a dietary supplement.

Safety: Use under professional lab protocols; store at ≤–20 °C.

FDA Notice: Statements have not been evaluated by FDA. Not intended to diagnose, treat, cure, or prevent any disease.

All products offered by TheraTide USA are strictly intended for research and development purposes only.

None of the statements on this website have been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

TheraTide USA is a research chemical supplier. We are not a compounding pharmacy or a chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act.

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