Product Overview
Compound: 5‑Amino‑1MQ (5‑amino‑1‑methylquinolinium), potent inhibitor of Nicotinamide N‑Methyltransferase (NNMT)
Form: 60 capsules at 50 mg each; high-purity research-grade compound.
For laboratory research only—NOT for human or veterinary use.
Batch-tested ≥98 % purity by HPLC. COA available on request — contact providers@theratideusa.com.
- NNMT inhibition: Effectively blocks nicotinamide methylation, reducing 1‑MNA and increasing NAD+ and SAM levels in adipocytes; EC₅₀ ≈2.3 µM in vitro :contentReference[oaicite:1]{index=1}.
- Anti‑lipogenic effects: Suppresses fat formation in 3T3‑L1 cells by 50–70% at 30–60 µM doses :contentReference[oaicite:2]{index=2}.
- Weight loss in vivo: In diet-induced obese mice (20 mg/kg SC, t.i.d., 11 days), achieved ~5% weight loss, ~35% fat pad reduction, and ~30% cholesterol reduction without appetite suppression :contentReference[oaicite:3]{index=3}.
- Metabolic benefits: Combined with a low-fat diet, normalizes adiposity and liver health; reshapes gut microbiome :contentReference[oaicite:4]{index=4}.
- Selectivity: Shows minimal off-target effects on other methyltransferases (DNMT1, PRMT3, COMT), NAMPT, and SIRT1 :contentReference[oaicite:5]{index=5}.
This data is from pre‑clinical cell and animal studies; no human trials have been conducted yet.
What is 5‑Amino‑1MQ used for?
It's used in research to block NNMT, promoting NAD⁺ and SAM elevation, reducing fat accumulation, and improving metabolic health.
How is it dosed?
In animal studies: typically 20 mg/kg SC three times daily for ~2 weeks.
Side effects?
Preclinical data shows no appetite suppression or toxicity at efficacious doses.
Administration?
Lab use involves oral or injected dosing; encapsulated for ease of use.
Human studies?
Not yet conducted—research remains at preclinical stage.
For research use only—NOT for human or veterinary use, nor as a dietary supplement.
Safety: Use under strict laboratory protocols with proper PPE and storage at ≤–20 °C.
FDA Notice: These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent disease.