Product Overview
Product Overview
Retatrutide Overview
Retatrutide is a novel triple receptor agonist peptide developed by Eli Lilly that simultaneously targets the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). The peptide’s mechanism of action involves reducing food intake, increasing energy expenditure, and potentially stimulating hepatic fatty acid oxidation while reducing hepatic lipogenesis.
Retatrutide in Weight Loss and Obesity
Retatrutide has shown promising results in clinical trials for weight loss and obesity treatment. In a phase 2 trial involving adults with obesity or overweight, retatrutide demonstrated substantial weight reduction over 48 weeks. Participants receiving the highest dose of retatrutide experienced a mean weight loss of 24.2% of their body weight, equivalent to about 58 pounds.
Retatrutide in Type 2 Diabetes
Recent clinical research has shown promising results for retatrutide in people with type 2 diabetes. In a phase 2 clinical trial, retatrutide demonstrated significant improvements in glycemic control and substantial weight loss over a 36-week period. Participants lowered their HbA1c by 1.3% to 2.0%, with up to 82% achieving an A1C below 6.5% and up to 31% reaching below 5.7%, indicating potential normalization of blood glucose levels.
Retatrutide Structure

Sequence: YA1QGTFTSDYSIL2LDKK4AQA1AFIEYLLEGGPSSGAPPPS3
Molecular Formula: C223H343F3N46O70
Molecular Weight: 4731.33 g/mol
PubChem SID: 474492335
CAS Number: 2381089-83-2
Synonyms: LY-3437943, NOP2Y096GV
Disclaimer
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.



Storage Instructions
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3–4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks, or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal to preserve the peptide’s stability.
For more details, see: Peptide Storage Information